Fri Oct 20 2023

88 articles - From Friday Oct 13 2023 to Friday Oct 20 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Endosc Int Open

Adherence to guideline recommendations for Barrett's esophagus (BE) surveillance endoscopies: Effects of dedicated BE endoscopy lists.

Dedicated endoscopy lists are associated with better adherence to the random biopsy protocol and surveillance interval recommendations.

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Gastroenterology

AGA Clinical Practice Update on the Role of Artificial Intelligence in Colon Polyp Diagnosis and Management: Commentary.

Methods This CPU was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership and underwent internal peer review by the CPUC and external peer review through standard procedures of Gastroenterology. This Expert Commentary incorporates important as well as recently published studies in this field, and it reflects the experiences of the authors who are experienced endoscopists with expertise in the field of artificial intelligence and colorectal polyps.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Systematic review with meta-analysis: Diagnostic performance of faecal calprotectin in distinguishing inflammatory bowel disease from irritable bowel syndrome in adults.

Faecal calprotectin is a reliable test in distinguishing patients with IBD from those with IBS. Faecal calprotectin seems to have a better sensitivity in Western countries and at a cut-off of =50 µg/g.

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Am J Gastroenterol

Prevalence and characteristics of covert/minimal hepatic encephalopathy in patients with liver cirrhosis: A systematic review and meta-analysis.

This study reports detailed data on the prevalence of C/MHE as well as clinical features associated with C/MHE, suggesting that C/MHE is one of the most common complications of liver cirrhosis.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Body weight increase and metabolic derangements after tenofovir disoproxil fumarate switch to tenofovir alafenamide in patients with chronic hepatitis B.

The switch from TDF to TAF was associated with weight gain, derangements of lipid profile, and increased insulin resistance in patients with CHB. Long-term effects on these metabolic features need further investigation.

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Development of a model to identify patients who do not need oesophageal biopsies when eosinophilic oesophagitis is suspected.

A simplified scoring system accurately identified a group of patients with a low likelihood of EoE where unnecessary oesophageal biopsies can be avoided, potentially resulting in resource and cost savings.

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Hepatobiliary disease after bone marrow transplant: A cross-sectional study of 377 patients.

Hepatobiliary complications are frequent in patients undergoing BMT. There is a greater risk of their occurrence in women, people with pre-BMT liver alterations, and in haploidentical transplants. The occurrence of these complications increases the length of stay and is associated with a higher risk of death.

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Long-term follow-up of web-based and group-based behavioural intervention in NAFLD in a real world clinical setting.

Although burdened by attrition, web-based behavioural intervention is feasible and effective in NAFLD, expanding the cohort involved in behavioural programs and reducing the risk of progressive disease.

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Superficial oesophageal mucosal innervation may contribute to severity of symptoms in oesophageal motility disorders.

Superficial location of mucosal nerves in the proximal oesophagus might contribute to symptoms, especially severe dysphagia, in disorders of OGJ outflow.

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The assessment of segmental healing by the Modified Mayo Endoscopic Score (MMES) complements the prediction of long-term clinical outcomes in patients with ulcerative colitis.

The MMES exhibited a benefit in predicting long-term outcome in UC even though endoscopic improvement remains the strongest predictor.

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Am J Gastroenterol

Diagnostic Performance of the ICD-10 Code K76.82 for Hepatic Encephalopathy in Patients with Cirrhosis.

Although K76.82 is promising, the combination term 'lactulose or rifaximin' identified patients with HE more accurately.

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Diagnostic Yield of Ambulatory Reflux Monitoring Systems for Evaluation of Chronic Laryngeal Symptoms.

In this multicenter, international study of patients with chronic laryngeal symptoms referred for LPR evaluation, diagnostic yield of ambulatory reflux monitoring off acid suppression was 36% and rose to 50% when using wireless pH monitoring. In patients referred for chronic laryngeal symptoms, 24h pH-impedance monitoring may risk a low negative predictive value in patients with unproven GERD.

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EFFECT OF GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONISTS ON BOWEL PREPARATION FOR COLONOSCOPY.

The use of GLP-1RAs was associated with a statistically significantly lower quality of bowel preparation, with additional clinical significance given a notable difference in the need for a repeat colonoscopy. It will be essential to understand the cumulative effect of medications that may delay gastric emptying on the quality of bowel preparation to better understand the appropriate measures and counseling that need to be taken before undergoing outpatient colonoscopies.

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Endoscopic features of post-COVID-19 cholangiopathy and its management using ERCP.

Gastrointestinal endoscopy makes an important contribution to the management of post-COVID-19 cholangiopathy. ERCP is not only of great diagnostic and prognostic value, but also has therapeutic value and therefore remains indispensable.

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Racial Disparities in Liver Disease Mortality Trends Among Black and White Populations in the United States, 1999-2020: An Analysis of CDC WONDER Database.

The rise in ALD and MASLD-related deaths among Whites, and enduring liver cancer and viral hepatitis disparities in the Black population, underscore the urgent need for tailored public health interventions.

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Endosc Int Open

A novel concept of passive loop-forming wire-guided biliary cannulation using an ultra-deep angled tip guidewire (with video).

Passive loop-forming WGBC using an ultra-deep angled tip guidewire is a feasible procedure.

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Additional information obtained from mucosal biopsies is limited after pan-enteric capsule endoscopy in patients with suspected Crohn's disease.

In patients with suspected CD and an evident result of CE, the additional information obtained from biopsies is limited, and CE as a single diagnostic procedure might be feasible in selected patients. Biopsies are warranted, however, in patients with an atypical endoscopic appearance or suspected malignancy.

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Capsule endoscopy with artificial intelligence-assisted technology: Real-world usage of a validated AI model for capsule image review.

AI-assisted reading has shown significant time savings without reducing sensitivity in this study. Limitations remain in the evaluation of other indicators.

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EUS-guided transcolonic drainage and necrosectomy in walled-off necrosis: a retrospective, single-center case series.

We included nine patients and found a technical success rate of 100%, clinical success in 89%, and one adverse event (11%). Transrectal/transcolonic endoscopic necrosectomy was needed in seven patients (78%).

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Efficacy and safety of cap-assisted endoscopic mucosal resection for superficial duodenal epithelial neoplasia = 10 mm.

We have demonstrated that EMRC is an effective and safe treatment for SDETs = 10 mm that do not have non-lifting signs.

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Optimal timing of simethicone administration prior to upper endoscopy: A multicenter, single-blind, randomized controlled trial.

Mucosal visibility can be optimized with early simethicone administration, either as a single administration or in a split-dose regimen.

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Endoscopy

A real-time deep learning-based system for colorectal polyp size estimation by white-light endoscopy: development and multicenter prospective validation.

ENDOANGEL-CPS could potentially improve the accuracy of colorectal polyp size measurements and size-based surveillance intervals.

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Direct diverticular peroral endoscopic myotomy for the treatment of thoracic esophageal diverticula: technique and outcomes.

DD-POEM was a safe technique for the management of thoracic esophageal diverticula. Owing to its simplicity and excellent performance it should be further evaluated for the treatment of this disorder.

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Effect of novel endoscope cleaning brush on duodenoscope contamination.

Use of the new brush in manual cleaning reduced contamination with MGO and is expected to prevent EAIs. These findings should be confirmed in future prospective randomized studies.

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Gastroenterology

A circulating panel of circRNA biomarkers for the noninvasive and early detection of pancreatic ductal adenocarcinoma.

We developed a circRNA-based biomarker panel with a robust noninvasive diagnostic potential for identifying patients with early-stage PDAC.

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High soluble fiber promotes colorectal tumorigenesis through modulating gut microbiota and metabolites in mice.

Moreover, transplanting stools from mice fed with high-inulin diet increased colonic cell proliferation and oncogene expressions in germ-free mice. High-dose soluble but not insoluble fiber potentiates colorectal tumorigenesis in a dose-dependent manner by dysregulating gut microbiota and metabolites in mice.

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Using Computer Vision to Improve Endoscopic Disease Quantification in Therapeutic Clinical Trials of Ulcerative Colitis.

As an automated and quantitative measure of global endoscopic disease severity, the CDS offers artificial intelligence enhancement of traditional MES capability to better evaluate UC in clinical trials and potentially practice.

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Gastrointest Endosc

ARTIFICAL INTELLIGENCE-ASSISTED REAL-TIME MONITORING OF EFFECTIVE WITHDRAWAL TIME DURING COLONOSCOPY: A NOVEL QUALITY MARKER OF COLONOSCOPY.

The AUC of EWT was also significantly higher than SWT on adenoma detection (0.80 [95%CI: 0.75 - 0.84] vs 0.70 [95%CI: 0.64-0.74], p <0.01). The AI-derived EWT monitoring is a promising novel quality indicator for colonoscopy, which is more associated with ADR than SWT.

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Development of Convolutional Neural Network Models That Recognize Normal Anatomical Structures During Real-Time Radial- and Linear-Array Endoscopic Ultrasound (with Videos).

The proposed CNN models accurately recognize the normal anatomical structures in prerecorded videos and real-time EUS. Prospective trials are needed to evaluate the impact of these models on the learning curves of EUS trainees.

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Endoscopic resection of giant esophageal subepithelial lesions: experience from a large tertiary center.

ER serves as a promising therapeutic option for esophageal g-SELs. A younger age, large tumor size, irregular shape and extraluminal growth may indicate increased ER difficulty, while a STER procedure tends to be of lower difficulty. Our nomogram model performs well to predict ER difficulty for esophageal g-SELs.

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Endoscopic sleeve gastroplasty as an early tool against obesity: a multicenter international study on an overweight population.

ESG is safe and effective in treating overweight patients with high BMI normalization rates. It could help halt or delay the progression to obesity.

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Hybrid Resection versus Conventional Resection for Laterally Spreading Lesions of the Papilla.

The novel hybrid resection technique for LSL-P management is associated with a high rate of RRA that is recalcitrant to treatment, without mitigating the risk of intraprocedural or delayed bleeding. Therefore, conventional hot-snare resection should remain the mainstay management option for treating patients with an LSL-P.

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Pancreatic Cyst Features Predict for Future Development of Pancreatic Cancer: Results of a Nested Case-Control Study.

Age, cyst size, cyst growth rate, and high-risk or worrisome features are associated with higher risk of developing pancreatic cancer. Applying current and developing novel strategies are required to optimize early detection of pancreatic cancer after cyst diagnosis.

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Performance of capsule endoscopy for the detection of small intestinal neuroendocrine tumor in familial carcinoid: a prospective single site study.

SB-CE is a sensitive and specific method comparable to 18 F-DOPA PET/CT for screening high-risk patients with familial SI-NET.

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Validation and update of clinical score model to predict technical difficulty of colorectal endoscopic submucosal dissection: A multicenter prospective cohort study.

The original model achieved an acceptable level of prediction in the prospective cohort. The updated model exhibited superior performance and can be used in place of the previous version.

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Hepatology

Complete correction of murine phenylketonuria by selection-enhanced hepatocyte transplantation.

We conclude that APAP-mediated selection of transplanted hepatocytes is a potential therapeutic for PKU with long-term efficacy and a favorable safety profile.

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J Hepatol

Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma.

Hypoxia-induced EC-specific DGKG hyper-expression promotes tumor angiogenesis and immune evasion via the ZEB2/TGF-ß1 axis, suggesting EC-specific DGKG as a potential therapeutic target for HCC.

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Higher TP53BP2 expression is associated with HBsAg loss in peginterferon-alpha-treated patients with chronic hepatitis B.

This finding not only provides an exciting predictor for HBsAg loss but identifies a potential therapeutic target for Peg-IFNa treatment. We believe our results are of great interest to a wide range of stakeholders, including patients and patient organizations, the medical community, academia, the life science industry, and the general public.

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Predicting survival in patients with 'non-high-risk' acute variceal bleeding receiving ß-blockers+ligation to prevent re-bleeding.

The majority of 'non-high-risk' patients with AVB have an excellent outcome, if treated according to current recommendations. However, about one fifth of patients, i.e., those with CTP =8 and/or high creatinine levels or hyponatremia, have a considerable risk of death within 1 year of the index bleed. Future clinical trials should investigate whether elective TIPS placement reduces mortality in these patients.

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Therapeutic vaccination with lentiviral vector in HBV-persistent mice and two inactive HBsAg carriers.

A lentiviral-vectored therapeutic vaccine for chronic HBV infection demonstrated the potential to improve HBV-specific T cell response and deplete HBV-positive hepatocytes, leading to a sustained loss or reduction of serum HBsAg.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Continuous monitoring to improve outcome of treatment-the next step towards safe and effective faecal microbiota transplantation.

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Editorial: Faecal microbiota transplantation in IBS-Moving closer or away from success?

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Editorial: Time to consider early treatment for chronic hepatitis B in both children and adults.

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Editorial: Unravelling the fibres-low dietary fibre may lower risk of developing IBD.

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Clin Gastroenterol Hepatol

Embracing Change: From NAFLD to MASLD under the Steatotic Liver Disease Umbrella.

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Gastroenterology

ADDITIONAL MEASURES AFTER STOPPING NUCLEOSIDE ANALOGUES IN HBEAG NEGATIVE CHRONIC HEPATITIS B: BETTER BUT NOT ENOUGH.

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Antireflux surgery does not prevent cancer in Barrett's esophagus.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

An unusual case of isolated gastric cap polyposis.

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Gastric Alimetry: A Reset of the Field of Gastric Electrophysiologic Testing for Nausea and Other Symptoms?

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Three-Dimensional Modeling to Guide Interventional Endoscopy in Fibrostenotic Crohn's Disease.

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Endoscopy

Cutting-edge novel device in the treatment of obesity.

Pubmed   Journal   ReadQx   PMC

Simplified endoscopic septotomy for a large symptomatic Zenker's diverticulum.

Pubmed   Journal   ReadQx   PMC

Single-use duodenoscopes: is performance enough? Time to include sustainability as a prerequisite in clinical practice.

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Gastroenterology

A Rare Cause of Cholestatic Liver Enzyme Elevation from a Common Entity.

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Approach to Remediating the Underperforming Endoscopic Trainee.

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Efficacy of Computer-aided Polyp Detection in Randomized Trials.

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Texture and Colour Enhancement Imaging Improves Colonic Adenoma Detection: A Multicentre Randomised Controlled Trial.

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Gastrointest Endosc

Endoscopic removal of a huge cecum fecalith hidden behind the ileocecal stricture in a patient with Crohn's disease.

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Gut

Akkermansia muciniphila derived tripeptide jams the gear of sepsis, inflammation and mortality.

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Hepatology

Author Index.

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Category Index.

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Cover Image.

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Instructions to Authors.

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Table of contents.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: Continuous monitoring to improve outcome of treatment-the next step towards safe and effective faecal microbiota transplantation. Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: Faecal microbiota transplantation in IBS-Moving closer or away from success? Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: Time to consider early treatment for chronic hepatitis B in both children and adults-authors' reply.

Pubmed   Journal   ReadQx 

Editorial: Unravelling the fibres-low dietary fibre may lower risk of developing IBD. Authors' reply.

Pubmed   Journal   ReadQx 

Letter: Association between aspirin use and risk of hepatocellular carcinoma in patients with chronic hepatitis B.

Pubmed   Journal   ReadQx 

Letter: Association between aspirin use and risk of hepatocellular carcinoma in patients with chronic hepatitis B.

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Letter: Consensus in international guidelines when discontinuing nucleos(t)ide analogue therapy in patients with chronic hepatitis B.

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Letter: Detecting unreported alcohol consumption in patients with NAFLD - Standardisation is urgent. Authors' reply.

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Letter: Detecting unreported alcohol consumption in patients with NAFLD-Standardisation is urgent.

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Letter: Exploring the clinical utility of ammonia in critically ill patients with cirrhosis: More to do?

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Letter: Exploring the clinical utility of ammonia in critically ill patients with cirrhosis: More to do? Authors' reply.

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Letter: Rethinking the lower incidence of HCC in HIV-infected patients- A closer look at confounding factors.

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Letter: Rethinking the lower incidence of HCC in HIV-infected patients-A closer look at confounding factors. Authors' reply.

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Gut

Functional predictors of pathogenicity of missense CPA1 variants in chronic pancreatitis.

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Increased incidence of GERD in GLP-1 treated patients: fact or artefact?

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Increased inflammatory state in IBD multiplex first-degree relatives not developing intestinal disease.

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J Hepatol

AUTHORS REPLY: High versus low target mean arterial pressure in septic shock in cirrhosis-A personalized TARGET-C approach may solve the conundrum!

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Anticoagulation for cirrhosis with portal vein thrombosis: Still a road to be explored.

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Challenges of Large Language models (LLMs) and the black box dilemma: The Aspect of interpretability in medicine.

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Changing from NAFLD to MASLD: The new definition can more accurately identify individuals at higher risk for diabetes.

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Comparing hypothermic oxygenated and normothermic liver machine perfusion: translation matters.

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Longitudinal changes in fatty liver index are associated with risk of hepatocellular carcinoma: A nationwide cohort study in Korea.

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Outcome of in-situ split liver transplantation in Italy over the last 25 years : an alternative analysis and personal view.

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Transitioning from NAFLD to MAFLD and MASLD: Consistent prevalence and risk factors in a Chinese cohort.

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